00100 - Statement - BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 00200 - Statement - STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 00500 - Statement - STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 40501 - Disclosure - Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 40601 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 40702 - Disclosure - Commitments and Contingencies - Operating Lease maturities (Details) (Cal2) link:presentationLink link:calculationLink link:definitionLink 00105 - Statement - BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00300 - Statement - STATEMENTS OF CONVERTIBLE PREFERRED STOCK (DEFICIT) link:presentationLink link:calculationLink link:definitionLink 00305 - Statement - STATEMENTS OF CONVERTIBLE PREFERRED STOCK (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00400 - Statement - STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) link:presentationLink link:calculationLink link:definitionLink 00405 - Statement - STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 40101 - Disclosure - Background (Details) link:presentationLink link:calculationLink link:definitionLink 40302 - Disclosure - Summary of Significant Accounting Policies - Potentially dilutive securities (Details) link:presentationLink link:calculationLink link:definitionLink 40401 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 40701 - Disclosure - Commitments and Contingencies - Lease (Details) link:presentationLink link:calculationLink link:definitionLink 40702 - Disclosure - Commitments and Contingencies - Operating Lease maturities (Details) link:presentationLink link:calculationLink link:definitionLink 40703 - Disclosure - Commitments and Contingencies - Aarvik Research Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 40801 - Disclosure - Stock-based Compensation - Plans (Details) link:presentationLink link:calculationLink link:definitionLink 40802 - Disclosure - Stock-based Compensation - Stock-based compensation expense (Details) link:presentationLink link:calculationLink link:definitionLink 40804 - Disclosure - Stock-based Compensation - Fair value (Details) link:presentationLink link:calculationLink link:definitionLink 40901 - Disclosure - Allist License Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 00090 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 10101 - Disclosure - Background link:presentationLink link:calculationLink link:definitionLink 10201 - Disclosure - Development-Stage Risks and Liquidity link:presentationLink link:calculationLink link:definitionLink 10301 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 10401 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 10501 - Disclosure - Prepaid Expenses and Other Current Assets link:presentationLink link:calculationLink link:definitionLink 10601 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 10701 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 10801 - Disclosure - Stock-based Compensation link:presentationLink link:calculationLink link:definitionLink 10901 - Disclosure - Allist License Agreement link:presentationLink link:calculationLink link:definitionLink 20302 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 30303 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 30403 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 30503 - Disclosure - Prepaid Expenses and Other Current Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 30603 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 30703 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 30803 - Disclosure - Stock-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 40201 - Disclosure - Development-Stage Risks and Liquidity (Details) link:presentationLink link:calculationLink link:definitionLink 40301 - Disclosure - Summary of Significant Accounting Policies - Net loss per share (Details) link:presentationLink link:calculationLink link:definitionLink 40303 - Disclosure - Summary of Significant Accounting Policies - Other (Details) link:presentationLink link:calculationLink link:definitionLink 40803 - Disclosure - Stock-based Compensation - Summary of stock options activity (Details) link:presentationLink link:calculationLink link:definitionLink 99900 - Disclosure - Standard And Custom Axis Domain Defaults link:presentationLink link:calculationLink link:definitionLink